反应详情

温度

60 °C

A mixture of methyl 5-bromothiophene-2-carboxylate (4 g), 1-(tert-butoxycarbonyl)pyrrole-2-boronic acid (3.8 g), dichlorobis (triphenylphosphine)palladium(II) (1.2 g) and 2M sodium carbonate solution (18 mL) in DME/water/ethanol (7/3/2, 200 mL) was heated at 60° C. for 4 hours, cooled and partitioned between ethyl acetate and brine. The extract was washed with water and concentrated, and the concentrate was flash chromatographed on silica gel with 5-40% ethyl acetate in hexane.

1. temperaturecooled
2. custompartitioned between ethyl acetate and brine
3. washThe extract was washed with water
4. concentrationconcentrated
5. customchromatographed on silica gel with 5-40% ethyl acetate in hexane