HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 5-(1-((Tert-butoxy)carbonyl)pyrrolidin-2-yl)thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tert-butyl 2-(5-(methoxycarbonyl)thiophen-2-yl)pyrrolidine-1-carboxylate | HCID 66758891 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-(1-((Tert-butoxy)carbonyl)pyrrolidin-2-yl)thiophene-2-carboxylic acid | HCID 66759426 | — |
Reaction Steps
To a mixture of EXAMPLE 34B (2.7 g) in THF (50 mL) was added lithium hydroxide (0.2 g) in water (5 mL). The mixture was stirred at ambient temperature overnight and partitioned between ethyl acetate and 0.5 M hydrochloric acid. The extract was washed with water, dried over magnesium sulfate, filtered and concentrated. The concentrate was flash chromatographed on silica gel with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067613B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-4de8ae4456854767ba8f8dfdece1e3d3 |
| Source note | uspto-grants-2011_11 |