反应详情

To a suspension of methyl 6-formylnicotinate (60 mg, 0.363 mmol) in methanol (3 mL) was added sodium methoxide in methanol (0.5M, 2.91 mL, 1.45 mmol). Tosylmethyl isocyanide (85 mg, 0.436 mmol) was added to the reaction and the mixture was heated at reflux overnight. After cooling, the reaction mixture was concentrated. The residue was treated with 5% citric acid/50% brine (1:1) and extracted with ethyl acetate. The suspension was filtered, washed with water, and dried under vacuum to provide the title compound. MS (DCI/NH3) m/z: 191.0 (M+1)+.

1. temperaturethe mixture was heated
2. temperatureat reflux overnight
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated
5. additionThe residue was treated with 5% citric acid/50% brine (1:1)
6. extractionextracted with ethyl acetate
7. filtrationThe suspension was filtered
8. washwashed with water
9. customdried under vacuum