HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (E)-N-(2-Amino-phenyl)-3-[1-(4-dimethylamino-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2-[(E)-3-[1-(4-dimethylamino-benzenesulfonyl)-1H-pyrrol-3-yl]-allanoylamino]-phenyl)-carbamic acid tert-butyl ester | HCID 86613979 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-N-(2-Amino-phenyl)-3-[1-(4-dimethylamino-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylamide | HCID 11625697 | — |
Reaction Steps
Starting materials: (2-{(E)-3-[1-(4-dimethylamino-benzenesulfonyl)-1H-pyrrol-3-yl]-allanoylamino}-phenyl)-carbamic acid tert-butyl ester (compound A8) (0.141 g), CH2Cl2 (10 ml), TFA (1 ml). Reaction conditions: room temperature, 20 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067615B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-d833724549124eca851872f2a2dc1643 |
| Source note | uspto-grants-2011_11 |