HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (E)-3-[1-(Biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| Reactant | tert-butyl (2E)-3-(1H-pyrrol-3-yl)prop-2-enoate | HCID 66646340 | — |
| Product | (E)-3-[1-(Biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester | HCID 66646172 | — |
Reaction Steps
Starting materials: sodium hydride 60% (0.207 g), (E)-3-(1H-pyrrol-3-yl)-acrylic acid tert-butyl ester (compound D1) (0.531 g), 4-biphenylsulphonylchloride (0.834 g). Reaction conditions: −30° C., 10 min; 30° C., 30 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067615B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-2abdedd2c71043feb858ca83d91a8789 |
| Source note | uspto-grants-2011_11 |