HRID564273

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)OCCNCCc1c[nH]c2ccccc12

HCID58756770

未命名化合物

2 次

结构：CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CBr)cc2)c1

HCID66646385

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CN(CCO[Si](C)(C)C(C)(C)C)CCc3c[nH]c4ccccc34)cc2)c1

HCID66646255

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[2-(1H-Indol-3-yl)-ethyl]-amine (compound E2) (830 mg, 2.60 mmol) is dissolved in ethanol (200 ml). (E)-3-[1-(4-bromomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester (compound D4) (1.01 g, 2.37 mmol) is added and the mixture is stirred for 43 hours and evaporated. The residue is purified by a silica gel flash chromatograph using petrol ether-ether eluent.

WORKUP

后处理

customevaporated
customThe residue is purified by a silica gel flash chromatograph

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0af202b57e634fe9a30e5b165c70d7b6
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08067615B2
来源说明: uspto-grants-2011_11

反应 SMILES

[C:1]([Si:5]([CH3:22])([CH3:21])[O:6][CH2:7][CH2:8][NH:9][CH2:10][CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][CH:13]=1)([CH3:4])([CH3:3])[CH3:2].[C:23]([O:27][C:28](=[O:47])/[CH:29]=[CH:30]/[C:31]1[CH:35]=[CH:34][N:33]([S:36]([C:39]2[CH:44]=[CH:43][C:42]([CH2:45]Br)=[CH:41][CH:40]=2)(=[O:38])=[O:37])[CH:32]=1)([CH3:26])([CH3:25])[CH3:24]>C(O)C>[C:23]([O:27][C:28](=[O:47])/[CH:29]=[CH:30]/[C:31]1[CH:35]=[CH:34][N:33]([S:36]([C:39]2[CH:44]=[CH:43][C:42]([CH2:45][N:9]([CH2:8][CH2:7][O:6][Si:5]([C:1]([CH3:2])([CH3:4])[CH3:3])([CH3:22])[CH3:21])[CH2:10][CH2:11][C:12]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[NH:14][CH:13]=3)=[CH:41][CH:40]=2)(=[O:38])=[O:37])[CH:32]=1)([CH3:26])([CH3:25])[CH3:24]