Potassium Carbonate → HCID 87233628, compound

Participants

Reaction Conditions

Reaction Steps

0.30 g of N-(2-bromo-6-methyl-4-hydroxyphenyl) 3-(benzoylamino)benzamide, 0.23 g of 1,1,1,3,3,3-hexafluoroisopropyl p-toluenesulfonate, 0.19 g of potassium carbonate and 0.03 g of 18-crown-6 ether were added to 5 ml of N,N-dimethylformamide, and the resulting mixture was stirred at 70° C. for 6 hours. 100 ml of ethyl acetate was added thereto and washed with water (50 ml×2). The organic phase was dried over anhydrous magnesium sulfate and the solvent was removed under a reduced pressure to obtain a residue. The resulting residue was purified by silica gel column chromatography (n-hexane EtOAc=3:1) to obtain 0.05 g of the desired product (Yield: 13%).

Provenance & Evidence