1-(2-Fluorophenyl)piperidin-4-one → N-[2-({(3R)-1-[1-(2-fluorophenyl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide

Participants

Reaction Steps

The title compound was synthesized in similar fashion to N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide, whereby 1-(2-fluorophenyl)piperidin-4-one was substituted for 1-(6-methoxypyridin-3-yl)piperidin-4-one, and was isolated as a white solid. 1H-NMR (CD3OD) δ: 1.86-1.92 (m, 2H), 2.03-2.22 (m, 3H), 2.41-2.48 (m, 1H), 2.75 (t, J=11.1 Hz, 2H), 3.16-3.26 (m, 1H), 3.36-3.44 (m, 2H), 3.54-3.66 (m, 4H), 4.04 (s, 2H), 4.51-4.55 (m, 1H), 6.96-7.10 (m, 4H), 7.70 (t, J=7.6 Hz, 2H), 7.87 (d, J=8.4 Hz, 1H), 8.15 (d, J=7.5 Hz, 1H), 8.22 (s, 1H), 8.36 (s, 2H). MS m/z: 493 (M+1)

Provenance & Evidence