6-Methoxy-3-pyridinylamine → N-(2-[((3R)-1-{1-[3-(aminocarbonyl)phenyl]piperidin-4-yl)pyrrolidin-3-yl)amino]-2-oxoethyl}-3-(trifluoromethyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	6-Methoxy-3-pyridinylamine	HCID 81121	—
Reactant	N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide	HCID 16722463	—
Product	N-(2-[((3R)-1-{1-[3-(aminocarbonyl)phenyl]piperidin-4-yl)pyrrolidin-3-yl)amino]-2-oxoethyl}-3-(trifluoromethyl)benzamide	HCID 57814098	—

Reaction Steps

N-(2-[((3R)-1-{1-[3-(aminocarbonyl)phenyl]piperidin-4-yl)pyrrolidin-3-yl)amino]-2-oxoethyl}-3-(trifluoromethyl)benzamide was synthesized in similar fashion to N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide, substituting 3-aminobenzamide for 6-methoxypyridin-3-amine. The crude product was purified by preparative HPLC. MS m/z: 518 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08067457B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-af792b1c39634798bf5a8ee9c769c25d
Source note	uspto-grants-2011_11