HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 564384Generated: October 26, 2026
N-but-3-en-1-yl-N-(4-methoxyphenyl)acrylamide → 1-(4-methoxyphenyl)-5,6-dihydropyridin-2(1H)-one
https://huagongshe.com/reaction/564384
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-but-3-en-1-yl-N-(4-methoxyphenyl)acrylamide | HCID 67004663 | — |
| Catalyst | HCID 178479819 | HCID 178479819 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-methoxyphenyl)-5,6-dihydropyridin-2(1H)-one | HCID 67005013 | 99.7% |
Reaction Steps
To a solution of N-but-3-en-1-yl-N-(4-methoxyphenyl)acrylamide (180 mg, 0.78 mmol) in degassed methylene chloride (200 mL) was added Grubbs catalyst (32 mg, 0.039 mmol) and the mixture was heated to 40° C. overnight. All volatiles were removed and the resulting material was subjected to flash chromatography (Hexanes:EtOAc 1:1) to yield 1-(4-methoxyphenyl)-5,6-dihydropyridin-2(1H)-one (158 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08067457B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-93f3b81a7a8b4863b9c90b2e0dfd89f6 |
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| Source note | uspto-grants-2011_11 |
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