1,4-Dioxane hydrochloride → HCID 67005165, compound

HRID 564386Notes

Reaction equation

HRID 564386 reaction equation
[O:1]=[C:2]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=1)[CH2:3][NH:4][C:5]([C@@H:7]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)=[O:6].[ClH:30].O1CCOCC1>O1CCOCC1>[ClH:30].[O:1]=[C:2]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:27])[F:28])[CH:21]=1)[CH2:3][NH:4][C:5]([C@@H:7]1[CH2:11][CH2:10][NH:9][CH2:8]1)=[O:6]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67004393HCID 67004393, compound

Product 1

HCID 67005165HCID 67005165, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl (3R)-3-{[(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethyl)amino]carbonyl}pyrrolidine-1-carboxylate (0.170 g, 0.41 mmol) in dioxane (0.5 ml), was added 4M HCl/dioxane (2 mL). The mixture was stirred at RT for 2 h. The mixture was concentrated, and (3R)—N-(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethyl)pyrrolidine-3-carboxamide hydrochloride was obtained as a white solid and was used in the next step without further purification.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-f43933d63b084e9db97616c85c18a756
Source dataset
uspto-grants-2011_11
Patent number
US08067457B2

Reaction notes

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