Benzoyl chloride, 3,4-dichloro- → HCID 67004347, compound

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The title compound was synthesized in similar fashion to 3,4-dichloro-N-[2-({(3R)-1-[1-(4-methoxyphenyl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl)benzamide, substituting 3-(trifluoromethoxy)benzoyl chloride for 3,4-dichlorobenzoylchloride, as well as 2-amino-N-[(3R)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl]acetamide for 2-amino-N-{(3R)-1-[1-(4-methoxyphenyl)piperidin-4-yl]pyrrolidin-3-yl}acetamide, and was isolated as a white solid. 1H-NMR (CDCl3) δ: 1.40-1.78 (m, 5H), 2.12-2.36 (m, 3H), 2.62 (d, J=5.4 Hz, 2H), 2.83 (m, 1H), 2.94 (m, 1H), 3.33 (m, 2H), 3.91 (m, 2H), 4.06 (d, J=5.4 Hz, 2H), 4.39 (m, 1H), 7.16 (d, J=7.8 Hz, 1H), 7.30 (m, 1H), 7.40 (t, J=8.0 Hz, 1H), 7.70 (m, 1H). MS m/z: 416 (M+1).

Provenance & Evidence