Ethyl Bromide → HCID 67005313, compound

Participants

Reaction Steps

The title compound was synthesized in similar fashion to rel-N-(2-{([(3R,4R)-4-ethoxy-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl]amino}-2-oxoethyl)-3-(trifluoromethyl)benzamide {[5-(trifluoromethyl)-1H-indazol-3-yl]amino}acetic acid was substituted for {[3-(trifluoromethyl)benzoyl]amino}acetic acid, and allyl bromide was substituted for bromoethane, and was isolated as a white solid. 1H-NMR (DMSO-d6) δ: 1.18-1.35 (m, 2H), 1.60-1.70 (m, 2H), 2.06-2.16 (m, 1H), 2.23-2.31 (m, 1H), 2.38-2.44 (m, 1H), 2.74-2.84 (m, 2H), 3.18-3.28 (m, 2H), 3.72-3.87 (m, 6H), 3.92-4.08 (m, 2H), 5.02-5.19 (m, 2H), 5.73-5.87 (m, 1H), 6.70 (t, 1H), 7.39 (d, 1H), 7.48 (dd, 1H), 8.03 (d, 1H), 8.26 (s, 1H), 11.9 (s, 1H). MS m/z: 468 (M+1).

Provenance & Evidence