反应详情

温度

0 °C

To a solution of 2-amino-3-(methyloxy)benzoic acid (15.0 g, 89.7 mmol) in MeOH (100 mL), NBS (16.8 g, 94.2 mmol) was added at −5° C. The reaction was kept stirring at 0° C. overnight, then put into the ice water under the condition of stirring. A precipitate formed and was filtered over Celite and dried in vacuo to afford 2-amino-5-bromo-3-(methyloxy)benzoic acid (22.0 g, 99%). 1H NMR (400 MHz, CDCl3): δ 7.65 (s, 1 H), 6.93 (s, 1 H), 3.87 (s, 3 H).

1. stirringof stirring
2. customA precipitate formed
3. filtrationwas filtered over Celite
4. customdried in vacuo