反应详情

Bromine (13.7 g, 86.0 mmol) in CHCl3 (20 mL) was added to the solution of 2-(methyloxy)benzonitrile (10.9 g, 81.9 mmol) in CHCl3 (50 mL). The mixture was refluxed for 29 h. The reaction was allowed to cool to room temperature, and washed with saturated sodium bisulfite (50 mL), and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate. Evaporation of the solvent afforded 5-bromo-2-(methyloxy)benzonitrile (12.4 g, 71%).

1. temperatureThe mixture was refluxed for 29 h
2. washwashed with saturated sodium bisulfite (50 mL), and brine (50 mL)
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. customEvaporation of the solvent