Hydrochloric Acid → 3-{[({3'-[(4-{[(1,1-Dimethylethyl)oxy]carbonyl}-1-piperazinyl)methyl]-6-fluoro-3-biphenylyl}methyl)amino]carbonyl}benzoic Acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 1,1-dimethylethyl 4-[(2′-fluoro-5′-{[({3-[(methyloxy)carbonyl]phenyl}carbonyl)amino]methyl}-3-biphenylyl)methyl]-1-piperazinecarboxylate (0.26 g, 0.463 mmol) in MeOH/H2O (2/1 mL) was added LiOH.H2O (0.0971 g, 2.32 mmol). The mixture was heated with a microwave at 80° C. for 30 min. Then HCl was added to adjust the pH to ˜5. Then solvents were removed. The residue was extracted with DCM to afford the title compound 0.256 g (100%). LC-MS m/z 548 (M+H)+.

Provenance & Evidence