Lithium Hydroxide → 3-[({[1,6-Diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)carbonyl]benzoic Acid

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-[({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)carbonyl]benzoate (705 mg, 1.514 mmol) in MeOH (4.5 mL) and H2O (2.250 mL) was added LiOH (181 mg, 7.57 mmol). This mixture was heated in a microwave at 80° C. for 30 min. The reaction mixture was concentrated, acidified with HCl to ph ˜5, filtered, and washed with MeOH/H2O (20%) to afford 0.5813 g (85%) of the title compound. LC-MS m/z 452 (M+H)+.

Provenance & Evidence