反应详情

1,1-Dimethylethyl 4-[(3′-cyano-3-biphenylyl)methylidene]-1-piperidinecarboxylate (0.517 g, 1.381 mmol) in methanol (138 mL) was applied on H-Cube hydrogenation apparatus. This resultant mixture was run with Pd(OH)2 cartridge at 1 mL/min, with 1 atmosphere at 20° C. HCl (1.38 mL, 1 N) was then added. One portion was run one time with a Pd(OH)2 cartridge at 1 mL/min, 1 atmosphere at 20° C. Another portion was run with 1 run with a Pd(OH)2 cartridge at 1 mL/min with 50 atmosphere and 20° C. Both portions were combined for 1 run using a Pd(OH)2 cartridge, under conditions of 1 mL/min with 1 atmosphere at 20° C. The reaction mixture was concentrated to afford the title compound (0.5008 g, 87%). LC-MS m/z 381 (M+H)+.

1. customat 20° C
2. customat 20° C
3. concentrationThe reaction mixture was concentrated