Ammonium Hydroxide → HCID 57813514, compound

Participants

Reaction Steps

N-{[1,6-Diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-N′-[(3′-formyl-6-methyl-3-biphenylyl)methyl]-1,3-benzenedicarboxamide (0.033 g, 0.05 mmol) and 1-methylpiperazine (0.025 g, 0.25 mmol) were combined in CH2Cl2 (2 mL) and stirred for 30 min. Sodium triacetoxyborohydride (0.053 g, 0.25 mmol) was added and the mixture stirred overnight. Aqueous workup followed using a Gilson HPLC with an ammonium hydroxide system gave the title compound as a white solid. LC-MS m/z 743.2 (M+H)+, 1.42 min (ret time); mp 121-124° C.

Provenance & Evidence