反应详情

A solution of 7-chlorofuro[2,3-c]pyridine (1.1 g) was stirred at room temperature under dry nitrogen in 1,4-dioxane (40 ml). Sodium methoxide (1.2 g) was added and the resulting mixture heated at reflux overnight. The mixture was diluted with water (100 ml) then extracted with ethyl acetate (3×100 ml). The combined organic extracts were washed with brine (50 ml), dried over magnesium sulfate, filtered and the solvent removed in vacuo to give the title compound (0.96 g) as a brown oil.

1. temperaturethe resulting mixture heated
2. temperatureat reflux overnight
3. extractionthen extracted with ethyl acetate (3×100 ml)
4. washThe combined organic extracts were washed with brine (50 ml)
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customthe solvent removed in vacuo