Formaldehyde → (7-Methoxyfuro[2,3-c]pyridin-2-yl)methanol

HRID 564714Notes

Reaction equation

HRID 564714 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][O:9][C:8]=12.[CH2:12]=[O:13]>>[CH3:1][O:2][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[C:10]([CH2:12][OH:13])[O:9][C:8]=12

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 105829307-Methoxyfuro[2,3-C]pyridine

Product 1

HCID 22112782(7-Methoxyfuro[2,3-c]pyridin-2-yl)methanol

Procedure

Starting from 7-methoxyfuro[2,3-c]pyridine (2.06 g) and formaldehyde (27 ml). Purification by column chromatography on silica eluting with 50% hexane in ethyl acetate gave the title compound (1.4 g) as a white solid.

Workup

  1. customPurification by column chromatography on silica eluting with 50% hexane in ethyl acetate

Sources & evidence

ORD record
ord-93d19ae269b249c3ad93d3a25c4be120
Source dataset
uspto-grants-2001_01
Patent number
US06169090A

Reaction notes

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