3-Oxotetrahydrofuran → HCID 22112793, compound

HRID 564715Notes

Reaction equation

HRID 564715 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][O:9][C:8]=12.[O:12]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13]1>>[CH3:1][O:2][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[C:10]([C:14]3([OH:17])[CH2:15][CH2:16][O:12][CH2:13]3)[O:9][C:8]=12

Participants

3

Reactant 2

HCID 5293923-OxotetrahydrofuranHCID 105829307-Methoxyfuro[2,3-C]pyridine

Product 1

HCID 22112793HCID 22112793, compoundYield 50.7%

Procedure

Starting from 7-methoxyfuro[2,3-c]pyridine (2.5 g) and dihydrofuran-3-one (1.7 g). Purification by column chromatography on silica eluting with 50% ethyl acetate in heptane afforded the title compound as a brown oil (2 g).

Workup

  1. customPurification by column chromatography on silica eluting with 50% ethyl acetate in heptane

Sources & evidence

ORD record
ord-a70660c2da324b2686d39cc878dda0a4
Source dataset
uspto-grants-2001_01
Patent number
US06169090A

Reaction notes

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