Triethylamine → HCID 22112806, compound

Participants

Reaction Steps

A solution of 4-(7-methoxyfuro[2,3-c]pyridin-2-yl)tetrahydopyran-4-ol (2.5 g) in dry dichloromethane (50 ml) was stirred at 0° C. under an atmosphere of dry nitrogen. Triethylamine (5.6 ml) was added followed by methanesulfonyl chloride (2.3 ml). The mixture was stirred overnight at room temperature. The solvent was removed in vacuo. Purification by column chromatography on silica eluting with 50% hexane in ethyl acetate gave 2-(3,6-dihydro-2H-pyran-4-yl)-7-methoxyfuro[2,3-c]pyridine (2.5 g) as a colourless oil.

Provenance & Evidence