反应详情

A solution of 2-acetyl-7-methoxyfuro[2,3-c]pyridine (1.1 g) in acetonitrile (50 ml) was stirred at room temperature. N-Bromosuccinimide (1.0 g) was added and stirring continued overnight. The reaction was quenched by the addition of water (50 ml) and extracted with dichloromethane (3×50 ml). The combined organic extracts were washed with water (50 ml), dried over magnesium sulfate, filtered and the solvent removed in vacuo. Purification by column chromatography on silica eluting with 33% ethyl acetate in hexane gave the title compound (1.4 g) as a white solid.

1. customThe reaction was quenched by the addition of water (50 ml)
2. extractionextracted with dichloromethane (3×50 ml)
3. washThe combined organic extracts were washed with water (50 ml)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customthe solvent removed in vacuo
7. customPurification by column chromatography on silica eluting with 33% ethyl acetate in hexane