Formic Acid → HCID 22112813, compound

Participants

Reaction Conditions

Reaction Steps

4-Bromo-7-methoxy-2-(4-methoxypiperidin-4-yl)furo[2,3-c]pyridine (1.2 g), formic acid (0.76 ml) and formaldehyde (37% w/w aqueous solution) (0.66 g) were combined and heated to 95° C. for 24 hours. The reaction mixture was then diluted with 2N sodium hydroxide solution (100 ml) and extracted with ethyl acetate (3×50 ml). The combined extracts were then dried over magnesium sulphate and evaporated in vacuo to give the title compound (0.96 g) as a pale yellow oil.

Provenance & Evidence