HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-3,5-dichloropyridine → 7-Methoxy-2-methoxymethylfuro[2,3-c]pyridine-4-carboxylic acid (3,5-dichloropyridin-4-yl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-3,5-dichloropyridine | HCID 89888 | — |
| Reactant | 7-Methoxy-2-methoxymethylfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester | HCID 54127291 | — |
| Product | 7-Methoxy-2-methoxymethylfuro[2,3-c]pyridine-4-carboxylic acid (3,5-dichloropyridin-4-yl)amide | HCID 44562337 | 90.8% |
Reaction Steps
Starting from 7-methoxy-2-methoxymethylfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (300 mg) and 4-amino-3,5-dichloropyridine (54 mg). Purification by column chromatography on silica eluting with 1% methanol in dichloromethane gave the title compound (115 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169090A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-c9549b1e28d040b991441d6d159086bf |
| Source note | uspto-grants-2001_01 |