HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-5-pyrimidinecarbonitrile → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-5-pyrimidinecarbonitrile | HCID 737208 | — |
| Reactant | 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester | HCID 54119345 | — |
| Product | 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amide | HCID 44365330 | 58.2% |
Reaction Steps
Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (200 mg) and 4-aminopyrimidine-5-carbonitrile (84 mg). Purification by trituration with ethyl acetate and methanol gave the title compound (110 mg) as an off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169090A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-1f803e18aa6941ada2a94ee8434d3e23 |
| Source note | uspto-grants-2001_01 |