HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-3,5-dichlorobenzonitrile → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (2,6-dichloro-4-cyanophenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-3,5-dichlorobenzonitrile | HCID 522706 | — |
| Reactant | 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester | HCID 54119345 | — |
| Product | 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (2,6-dichloro-4-cyanophenyl)amide | HCID 86756190 | 44.7% |
Reaction Steps
Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (0.10 g) and 4-amino-3,5-dichlorobenzonitrile (0.12 g). Purification by column chromatography on silica with 20% then 30% then 50% ethyl acetate in hexane to give the title compound (0.051 g) as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169090A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-a03d1dc6e8784a9fb0c11c71e9cbe82b |
| Source note | uspto-grants-2001_01 |