2,6-Difluoroaniline → HCID 44365329, compound

HRID 564739Notes

Reaction equation

HRID 564739 reaction equation
[N+](C1C=CC(O[C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=CC=1)([O-])=O.[F:26][C:27]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:28]=1[NH2:29]>>[F:26][C:27]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:28]=1[NH:29][C:11]([C:13]1[C:14]2[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=2[C:16]([O:19][CH3:20])=[N:17][CH:18]=1)=[O:12]

Participants

3

Reactant 2

HCID 796472,6-DifluoroanilineHCID 541193452-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester

Product 1

HCID 44365329HCID 44365329, compound

Procedure

Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (0.10 g) and 2,6-difluoroaniline (0.093 ml). Purification by column chromatography on silica with 30% ethyl acetate in hexane plus 1% ammonia solution, followed by trituration with ether gave the title compound (0.040 g) as a white solid.

Workup

  1. customPurification by column chromatography on silica with 30% ethyl acetate in hexane plus 1% ammonia solution

Sources & evidence

ORD record
ord-61fbe676e9e94fa2a40b29a57344bb78
Source dataset
uspto-grants-2001_01
Patent number
US06169090A

Reaction notes

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