HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-3-chloro-5-methylbenzonitrile → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (2-chloro-4-cyano-6-methylphenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-3-chloro-5-methylbenzonitrile | HCID 2735301 | — |
| Reactant | 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester | HCID 54119345 | — |
| Product | 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (2-chloro-4-cyano-6-methylphenyl)amide | HCID 44365343 | 42.6% |
Reaction Steps
Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (200 mg) and 4-amino-3-chloro-5-methylbenzonitrile (195 mg). Purification by column chromatography on silica eluting with 2% methanol in dichloromethane gave the title compound (92 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169090A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-d1a6b422098c423cb0aad4138fc6632a |
| Source note | uspto-grants-2001_01 |