HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroformate → S-(-)-Amisulpride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | (S)-(-)-2-Aminomethyl-1-ethylpyrrolidine | HCID 643457 | — |
| Reactant | 4-Amino-5-(ethylsulphonyl)-o-anisic acid | HCID 3018232 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | S-(-)-Amisulpride | HCID 3055076 | 84.9% |
Reaction Steps
95 g of 2-methoxy-4-amino-5-ethylsulphonylbenzoic acid dissolved in 370 ml of acetone, in the presence of 37 g of trielthylamine, is treated with 40 g of ethyl chloroformate with 57 g of (S)-(−)-1-ethyl-2-aminomethylpyrrolidine. 115 g of (S)-(−)-N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-amino-5-ethylsulphonylbenzamide is obtained (yield=84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169094A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-96b7f2ade85f45a3a8892a757cb44293 |
| Source note | uspto-grants-2001_01 |