P-Anisidine → HCID 178492416, compound

Participants

Reaction Steps

4-Amino-anisole (15 g, 0.12 mol) was dissolved in a mixture of concentrated hydrochloric acid (36 ml) and water (36 ml). To the resulting mixture was added dropwise at 5° C. a solution of sodium nitrite (9.2 g, 0.13 mol) in water (45 ml). The resulting diazonium salt was added to a mixture of sodium acetate (30 g, 0.37 mol), ethanol (125 ml) and pentane-2,4-dione (12.2 g, 0.12 mol) at room temperature. The resulting mixture was stirred for 1 h at room temperature. The precipitate was filtered off and washed with water (2×150 ml), ethanol (2×50 ml) and dried in vacuo at 50° C. for 18 h affording 17 g (60%) of 3-[(4-methoxy-phenyl)-hydrazono]-pentane-2,4-dione as a solid.

Provenance & Evidence