反应详情

6-Chloro-3H-pyrido[3,4-d]pyrimidin-4-one was reacted with dimethylamine (2.0 molar solution in methanol) in a pressure vessel at 130° C. for 32 hours. The reaction mixture was concentrated in vacuo and the resulting solid washed with ethyl acetate. This solid was heated in 2-propanol to give a suspension, which was filtered. The filtrate was concentrated in vacuo to give the product (60%).

1. concentrationThe reaction mixture was concentrated in vacuo
2. washthe resulting solid washed with ethyl acetate
3. temperatureThis solid was heated in 2-propanol
4. customto give a suspension, which
5. filtrationwas filtered
6. concentrationThe filtrate was concentrated in vacuo