4-(4-Benzyloxyanilino)6-chloropyrido[3,4-d]pyrimidine → HCID 22112852, compound

HRID 564763Notes

Reaction equation

HRID 564763 reaction equation
[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([NH:13][C:14]2[C:15]3[CH:23]=[C:22](Cl)[N:21]=[CH:20][C:16]=3[N:17]=[CH:18][N:19]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[N:32]1[CH2:36][CH:35]=[CH:34][N:33]1[CH3:37])CCC>>[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([NH:13][C:14]2[C:15]3[CH:23]=[C:22]([N:32]4[CH2:36][CH:35]=[CH:34][N:33]4[CH3:37])[N:21]=[CH:20][C:16]=3[N:17]=[CH:18][N:19]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 219521684-(4-Benzyloxyanilino)6-chloropyrido[3,4-d]pyrimidineHCID 22112886HCID 22112886, compound

Product 1

HCID 22112852HCID 22112852, compound

Procedure

Prepared according to Procedure B from 4-(4-benzyloxyanilino)6-chloropyrido[3,4-d]pyrimidine and 2-(tri-n-butylstannyl)-N-methylpyrazole (prepared according to the published method: WO 94/00825); δH [2H6]-DMSO 9.30 (1H,s), 8.80 (2H,m), 7.80 (2H,d), 7.65 (1H,d), 7.50 (6H,m), 7.20 (2H,d), 6.90 (1H,d), 5.20 (2H,s), 4.25 (3H,s); m/z (M+1)+409.

Workup

  1. customPrepared
  2. customprepared

Sources & evidence

ORD record
ord-fba33fbcd3ce4b13884606d3035817c8
Source dataset
uspto-grants-2001_01
Patent number
US06169091A

Reaction notes

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