Thiomorpholine → HCID 22112860, compound

HRID 564768Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([NH:13][C:14]2[C:15]3[CH:23]=[C:22](Cl)[N:21]=[CH:20][C:16]=3[N:17]=[CH:18][N:19]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:27]1[CH2:32][CH2:31][S:30][CH2:29][CH2:28]1>>[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([NH:13][C:14]2[C:15]3[CH:23]=[C:22]([N:27]4[CH2:32][CH2:31][S:30][CH2:29][CH2:28]4)[N:21]=[CH:20][C:16]=3[N:17]=[CH:18][N:19]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 67164Thiomorpholine

HCID 219521684-(4-Benzyloxyanilino)6-chloropyrido[3,4-d]pyrimidine

Product 1

HCID 22112860HCID 22112860, compound

Procedure

Prepared according to Procedure C from 4-(4-benzyloxyanilino)-6-chloropyrido[3,4-d]pyrimidine and thiomorpholine; δH (CDCl3) 9.00 (1H,s), 8.59 (1H,s), 7.59 (2H, d), 7.28-7.50 (5H,m), 7.03 (2H,d), 6.56 (1H,s), 5.09 (2H,s), 3.92-4.18 (4H,m), 2.62-2.92 (4H,m); m/z (M+1)+430.

Workup

customPrepared

Sources & evidence

ORD record: ord-99860e07daae4351a024ee3324f83d2e
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06169091A

Reaction notes

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