4,6-Dichloropyrido[3,4-d]pyrimidine → HCID 88216020, compound

HRID 564776Notes

Reaction equation

HRID 564776 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][O:7][C:8]1[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=1.[Cl:15][C:16]1[C:17]2[CH:25]=[C:24]([Cl:26])[N:23]=[CH:22][C:18]=2[N:19]=[CH:20][N:21]=1>>[ClH:15].[Cl:26][C:24]1[N:23]=[CH:22][C:18]2[N:19]=[CH:20][N:21]=[C:16]([NH:12][C:11]3[CH:10]=[CH:9][C:8]([O:7][CH2:6][CH:2]4[O:3][CH2:4][CH2:5][O:1]4)=[CH:14][CH:13]=3)[C:17]=2[CH:25]=1

Participants

3

Reactant 2

HCID 108218764,6-Dichloropyrido[3,4-d]pyrimidineHCID 22112838HCID 22112838, compound

Product 1

HCID 88216020HCID 88216020, compound

Procedure

Prepared according to Procedure A from 4-(1,3-dioxolan-2-yl)methoxyaniline (prepared according to the published method: WO 96/09294) and 4,6-dichloropyrido[3,4-d]pyrimidine; δH [2H6]-DMSO 9.06 (1H,s), 8.85 (1H,s), 8.79 (1H,s), 7.73 (2H,d), 7.05 (2H,d), 5.21 (1H,t), 3.70-4.06 (6H,m); m/z (M+1)+359.

Workup

  1. customPrepared
  2. customprepared

Sources & evidence

ORD record
ord-bed99eec746e480e86eb03ef4e386f30
Source dataset
uspto-grants-2001_01
Patent number
US06169091A

Reaction notes

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