Dimethylamine → HCID 22112833, compound

HRID 564777Notes

Reaction equation

Cl[C:2]1[N:25]=[CH:24][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]4[O:23][CH2:22][CH2:21][O:20]4)=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[CH3:26][NH:27][CH3:28]>>[CH3:26][N:27]([C:2]1[N:25]=[CH:24][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]4[O:23][CH2:22][CH2:21][O:20]4)=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1)[CH3:28]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 22112868HCID 22112868, compound

Product 1

HCID 22112833HCID 22112833, compound

Procedure

Prepared according to Procedure C from 6-chloro-4-[4-(1,3-dioxolan-2-yl)methoxyanilino]pyrido[3,4-d]pyrimidin and dimethylamine (33% aqueous solution); δH (CDCl3) 9.71 (1H,s), 8.87 (1H,s), 8.38 (1H,s), 7.78 (2H,d), 7.35 (1H,s) 7.09 (2H,d), 5.30 (1H,t), 4.00 (6H,m), 3.25 (6H,s); m/z (M+1)+368.

Workup

customPrepared

Sources & evidence

ORD record: ord-4bedadf01df04d6abecbcf050b04035e
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06169091A

Reaction notes

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