(4-Aminophenoxy)benzene → HCID 22112879, compound

Participants

Reaction Steps

4-Chloro-5-methylthieno[2,3-d]pyrimidine (0.185 g, 1.00 mmol) and 4-phenoxyaniline (0.210 g, 1.1 mmol) were reacted in 2-propanol (6 ml) for 17 hours according to Procedure A. The product was obtained as a pale grey solid (0.297 g, 80%), m.p. 218-221° C.; (Found: C, 61.61; H, 4.33, N, 11.25. C19H15N3OS.HCl requires: C, 61.70; H, 4.36; N, 11.36%); δH [2H6]-DMSO 8.60 (1H, br s, NH), 8.49 (1H, s, 2-H), 7.68 (2H, d, J 9, 2′-H, 6′-H), 7.33-7.48 (3H, m, 6-H, 3″-H, 5″-H), 7.17 (1H, t, J 9, 4″-H), 7.00-7.10 (4H, m, 3′-H, 5′-H, 2″-H, 6″-H), 2.75 (3H, s, 5-CH3); m/z 333 (M+).

Provenance & Evidence