HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-(Pyridin-2-ylmethoxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | 4-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine | HCID 22727453 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Pyridin-2-ylmethoxy)aniline | HCID 10442773 | — |
Reaction Steps
4-(2-Pyridylmethoxy)aniline was prepared from 4-nitrophenol (Aldrich) and 2-picolyl chloride hydrochloride (Aldrich) according to Procedure D. This was reacted with 4-chloro-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine according to Procedure A to give the product; tlc (dichloromethane:ethanol:aq.ammonia, 100:8:1) Rf 0.37; m/z (M+1)+373.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169091A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-01aef3370bab46bda363e995445e063c |
| Source note | uspto-grants-2001_01 |