HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-(3-Fluoro-benzyloxy)-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | 3-Fluorobenzyl bromide | HCID 68007 | — |
| Reactant | 4-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine | HCID 22727453 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-Fluoro-benzyloxy)-phenylamine | HCID 16775314 | — |
Reaction Steps
4-(3-Fluorobenzyloxy)aniline was prepared from 4-nitrophenol (Aldrich) and 3-fluorobenzylbromide (Aldrich) according to Procedure D. This was reacted with 4-chloro-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine according to Procedure A to give the product; tic (dichloromethane:ethanol:aq.ammonia, 100:8:1) Rf 0.48; m/z (M+1 )+390.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169091A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-2a968be830164788a87af789fdf0c990 |
| Source note | uspto-grants-2001_01 |