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HRID564802

反应详情

EQUATION

反应方程式

HRID 564802 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

结构：O=C(N1CCc2ccc(S(=O)(=O)Cl)cc2C1)C(F)(F)F
HCID11324902

2-(Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

C11H9ClF3NO3S

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc3c(c2)CNCC3)CC1
HCID18765175

未命名化合物

收率 35%

PROCEDURE

实验过程

The subtitle compound was prepared by the method of Example 16(a) from 1-t-butyloxycarbonylpiperazine and 2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride. The product was purified on silica gel, eluting with CH2Cl2/MeOH (93/7, v/v) to afford the subtitle compound (35%) as a colourless solid. Rf 0.56 (CH2Cl2/MeOH 9/1, v/v). MS m/z 382 (MH+).

WORKUP

后处理

  1. customThe product was purified on silica gel
  2. washeluting with CH2Cl2/MeOH (93/7