Acetyl chloride → HCID 18473942, compound

Participants

Reaction Conditions

Reaction Steps

2-amino-5-[1-(indol-3-yl)ethyl]-2-oxazolin-4-one (300 mg) was dissolved into tetrahydrofuran (2 ml). Triethylamine (344 μl) and acetyl chloride (123 μl) were added under ice cooling. The mixture was stirred for 2 hours at 0° C. Triethylamine (344 μl) and acetyl chloride (123 μl) were added again. The whole was further stirred for 2 hours. To the reaction mixture was added water and the whole was extracted with ethyl acetate. The extract was washed with brine and dried over magnesium sulfate. Concentration of the solution gave a residue, which was subjected to silica gel chromatography. The eluent with hexane-acetone (1:1) was collected and concentrated to provide the titled compound (40 mg).

Provenance & Evidence