1-[2-Amino-6-(4-methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolecarbaldehyde → Ethyl 3-[1-[2-Amino-6-(4-methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolyl]-2-trans-propenoate

HRID 564875Notes

Reaction equation

HRID 564875 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:12]([CH3:13])=[C:11](C=O)[CH:10]=[N:9]2)[CH:5]=[C:4]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[N:3]=1.[C:26]([CH:31]=[C:32]1CCP(C2C=CC=CC=2)C1(C1C=CC=CC=1)C1C=CC=CC=1)([O:28][CH2:29][CH3:30])=[O:27]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:12]([CH3:13])=[C:11](/[CH:32]=[CH:31]/[C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH:10]=[N:9]2)[CH:5]=[C:4]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[N:3]=1

Participants

3

Reactant 2

HCID 185453431-[2-Amino-6-(4-methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolecarbaldehydeHCID 68574662(Carbethoxymethylene)triphenylphospholane

Product 1

HCID 18545316Ethyl 3-[1-[2-Amino-6-(4-methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolyl]-2-trans-propenoate

Procedure

The compound obtained in (2) above weighing 3.50 g and 4.3 g of (carboethoxymethylene)triphenylphospholane were allowed to react and worked up in the same manner as in Example 57-(3) to give 3.22 g of the title compound as a white solid.

Workup

  1. customto react

Sources & evidence

ORD record
ord-f7866ed56db6421197cb9446719ebe17
Source dataset
uspto-grants-2001_01
Patent number
US06169086A

Reaction notes

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