HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 564881Generated: November 3, 2026
Dichloromethane → HCID 18630839, compound
https://huagongshe.com/reaction/564881
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 18319934 | HCID 18319934 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 18630839 | HCID 18630839 | — |
Reaction Steps
A mixture of intermediate 12 (0.032 mol) in HCl, (6N; 90 ml) was stirred at 75° C., then cooled. CH2Cl2 was added and the mixture was alkalized with NaOH at a temperature below 20° C. The organic layer was separated, dried, filtered and the solvent was evaporated. The residue was dried, yielding 7.2 g of 2-[(3,4-difluorophenyl)methyl]-4-piperidinone (intermediate 13).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06169097A |
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| Source dataset | uspto-grants-2001_01 |
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| ORD ID | ord-a640baa4194241c9961360928af8ed94 |
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| Source note | uspto-grants-2001_01 |
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