HCID 86756201, compound → HCID 70221472, compound

Participants

Reaction Steps

A solution of (±)-ethyl cis-1-[1-(3,5dimethylbenzoyl)-2-(phenylmethyl)-4-piperidinyl]-4-phenyl-4-piperidinecarboxylate (2.96 g) in NaOH (20 ml) and dioxane (50 ml) was stirred and refluxed for 30 hours. The mixture was evaporated and HCl, (1N; 20 ml) was added. The precipitate was filtered off, water (100 ml) and CH2Cl2 (10 ml) were added and filtered again. The precipitate was taken up in water, heated, cooled, filtered off and dried. The product was purified by HPLC (eluent: ammoniumacetate and CH3CN). The pure fractions were collected, evaporated and dried, yielding 1.09 g (39%) of (±)-cis-1-[1-(3,5-dimethylbenzoyl)-2-(phenylmethyl)-4-piperidinyl]-4-phenyl-4-piperidinecarboxylic acid (compound 38, mp. 259.1° C.).

Provenance & Evidence