反应详情

A mixture of benzyl N-(2-methoxyethyl)-N-(3-pyridylmethyl)carbamate (5.4 g) and 10% palladium on carbon (1.0 g) in ethanol (50 ml) was stirred under hydrogen atmosphere for 9 hours. The catalyst was removed by filtration, and the filtrate was concentrated under azeotropic condition with toluene and ethanol. The residue was dissolved in ethanol and diethyl ether was added thereto to give precipitates, which were collected by filtration to give N-(2-methoxyethyl)-N-(3-pyridylmethyl)amine (1.3 g).

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated under azeotropic condition with toluene and ethanol
3. dissolutionThe residue was dissolved in ethanol
4. additiondiethyl ether was added
5. customto give
6. customprecipitates
7. filtrationwhich were collected by filtration