反应详情

A mixture of 2-acetylamino-5-formylpyridine (241 mg) and malonic acid (168 mg) in pyridine (0.12 ml) and ethanol (0.36 ml) was refluxed for 2 hours. After cooling the mixture, the precipitate was collected by filtration, and washed with ethyl acetate to give (E)-3-(6-acetylamino-3-pyridyl)acrylic acid (248 mg) as a colorless powder.

1. temperaturewas refluxed for 2 hours
2. temperatureAfter cooling the mixture
3. filtrationthe precipitate was collected by filtration
4. washwashed with ethyl acetate