反应详情

A mixture of 5.20 g (19.9 mmol) of ethyl 7-carbomethoxy-1-methyl-2-indolecarboxylate, 90 ml of 2N sodium hydroxide and 150 ml of ethanol was refluxed for 3 hours. The reaction mixture was concentrated under reduced pressure and ice water was added to the residue. 2N hydrochloric acid was added to acidify the reaction mixture. The precipitated solid was filtered and dried under reduced pressure to give 4.70 g (>99%) of 1-methylindole-2,7-dicarboxylic acid.

1. temperaturewas refluxed for 3 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure and ice water
3. additionwas added to the residue
4. addition2N hydrochloric acid was added
5. filtrationThe precipitated solid was filtered
6. customdried under reduced pressure