Ethyl (3-benzyloxy-6-trifluoromethyl-2-nitrophenyl)pyruvate → 4-(Trifluoromethyl)-7-(benzyloxy)-1H-indole-2-carboxylic acid ethyl ester

Participants

Reaction Steps

The reaction was carried out in a manner similar to Reference Example 12 c) except for using 10.9 g (26.7 mmol) of ethyl (3-benzyloxy-6-trifluoromethyl-2-nitrophenyl)pyruvate, 165 g (213 mol) of 20% titanium chloride aqueous solution and 100 ml of ethanol. Ethyl 7-benzyloxy-4-trifluoromethyl-2-indolecarboxylate was thus obtained in the yield of 8.00 g (82.6%).

Provenance & Evidence