HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethyl 7-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Trifluoromethyl)-7-(benzyloxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 21194052 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 7-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate | HCID 21194661 | — |
Reaction Steps
The reaction was carried out in a manner similar to Reference Example 18 a) except for using 8.00 g (22.0 mmol) of ethyl 7-benzyloxy-4-trifluoromethyl-2-indolecarboxylate, 0.88 g (22.0 mmol) of 60% sodium hydride, 6.25 g (44.0 mmol) of methyl iodide and 150 ml of dimethylformamide. Ethyl 7-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate was thus obtained in the yield of 7.40 g (89.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169107A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-c4fc17d5903a4824b3fdda2a698836bd |
| Source note | uspto-grants-2001_01 |